Samples of plasma drawn from 12 people who received the Pfizer-BioNTech vaccine were tested as part of a rapid response to the variant, which recently emerged in Africa and has triggered travel bans across the world.
The results? A 41-fold decline in antibodies.
The research suggests the variant “escapes antibody immunity induced by the Pfizer-BioNTech vaccine,” the Africa Health Research Institute said.
Several scientists with the research, based in Durban, collaborated on the study with other researchers in Africa.
Researchers did find evidence that those who were vaccinated and had recovered from COVID-19 saw less of a reduction in protection.
“Previous infection + vaccination still neutralizes,” Alex Sigal, one of the researchers, wrote on Twitter.
It was not clear why unvaccinated persons with natural immunity weren’t part of the study and Sigal and another researchers did not respond to requests for comment.
The study (pdf) has not been peer reviewed or even uploaded yet to the preprint medRxiv server yet.
But scientists around the world immediately began sharing the results, as South African scientists first identified Omicron and there is scant data about its impact on vaccines.
Jeremy Farrar, director of the Wellcome Trust, called the work “hugely important” and found the results “sobering.” Florian Krammer, a microbiology professor at the Icahn School of Medicine at Mount Sinai, said the study showed a “huge drop” in protection. Dr. Ashish Jha, dean of Brown University’s School of Public Health, said the drop was “not great” but “not terrible” and that the study provided more evidence of the need for booster shots.
Others sought to emphasize that antibodies aren’t the only form of protection that vaccination triggers.
“Although antibodies (our main line of defense for upper respiratory tract symptoms e.g. mild breakthroughs) can wane over time or be affected by mutations along the spike protein, T cells from the vaccine still work against Omicron and B cells (generated by the vaccines) adapt the new antibodies they produce to work against variants,” Dr. Monica Gandhi, a professor of medicine at the University of California, San Francisco, told The Epoch Times in an email, pointing to several studies and news reports.
Pfizer and BioNTech did not respond to requests for comment.
Dr. Uğur Şahin, CEO of BioNTech, told NBC after the new study was released that the company is expecting its own results this week from tests against Omicron. He described himself as “optimistic.”
A previous study from South Africa suggested people with natural immunity may have less protection against Omicron. An emergency room doctor in the United States, meanwhile, said the variant may itself provide natural immunity without inducing severe illness, noting many cases so far have shown no or few symptoms.
“It appears that with the cases that are seen, we are not seeing a very severe profile of disease,” Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, told reporters during a virtual briefing on Tuesday.
Fauci said U.S. researchers expect results next week for testing on live virus and pseudo virus assays. Other researchers are studying Omicron on animals and against antivirals.
From The Epoch Times